Exercise in a Bottle? The Promise of α-Klotho Biologics for Age-Related Cognitive Decline

Thu, 27 Jun 2024 00:00:00 +0000

I came across a recent podcast by Peter Attia M.D. where he interviews Dena Dubal M.D. Ph.D. on a potential “breakthrough in Alzheimer’s disease” in the form of α-klotho supplementation. α-klotho, often referred to as just “klotho,” is a transmembrane protein expressed in the brain, liver, and kidney. Klotho seems to have several mechanisms of control over different metabolic pathways, including insulin sensitivity, maintaining calcium homeostasis, mitigating oxidative stress and endothelial dysfunction, facilitating oligodendrocyte maturation, myelin integrity, and a host of other functions. ¹

Dementia on Scott Gilmore, MD

Exercise in a Bottle? The Promise of α-Klotho Biologics for Age-Related Cognitive Decline